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Content preview:  I have a distant memory of a problem that was a lot like this,
   and as with your situation, a reboot always cured it. Ends up the source
  of the problem was the spool directory became unusable because the volume
  it was on getting full. Any chance you have something going on each weekend
   that leaves behind a lot of temporary files on the same volume that holds
   the spool files? [...] 

Content analysis details:   (5.8 points, 5.0 required)

 pts rule name              description
---- ---------------------- --------------------------------------------------
 3.4 FH_DATE_PAST_20XX      The date is grossly in the future.
 2.4 DNS_FROM_OPENWHOIS     RBL: Envelope sender listed in bl.open-whois.org.